| Children |
| | 1. John Thomas Lewis, b. 1826, Maryland d. Yes, date unknown |
| | 2. Thomas B. Lewis, b. 1829, Baltimore, Baltimore, Maryland d. Oct 1868 (Age 39 years) |
| | 3. William M. Lewis, b. 1834, Baltimore, Baltimore, Maryland d. Yes, date unknown |
| | 4. Gertrude Jane Lewis, b. 1835, Maryland d. Aug 1895, Maryland (Age 60 years) |
| | 5. Joseph Nathan Lewis, Jr., b. 1836, Baltimore, Baltimore, Maryland d. 18 Jun 1861 (Age 25 years) |
| | 6. Paca Smith Lewis, b. 1839, Baltimore, Baltimore, Maryland d. 24 Sep 1885, St. Louis, St. Louis, Missouri (Age 46 years) |
| | 7. Francis Lewis, b. 1843, Baltimore, Baltimore, Maryland d. Bef 1900, Maryland (Age 56 years) |
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